Lilly says retatrutide eased sleep apnea, knee pain

June 8, 2026

1–2 minutes

Summary

Lilly said trial data showed retatrutide reduced sleep apnea severity and knee pain while supporting weight loss.

Why this matters

The results add to evidence on whether next-generation obesity drugs may help treat related conditions beyond weight loss. They also matter in a competitive obesity and diabetes drug market led by Eli Lilly and Novo Nordisk.

Eli Lilly presented trial results on Saturday showing its experimental obesity drug retatrutide reduced sleep apnea severity, eased knee osteoarthritis pain, and supported weight loss.

In a Phase 3 trial, Lilly said a weekly injection of retatrutide reduced moderate-to-severe obstructive sleep apnea severity by 60.6% in adults with obesity. Lilly’s older drug Zepbound is already approved for that condition.

In the same trial, Lilly said retatrutide reduced knee osteoarthritis pain by up to 73.1%. The results were presented at the American Diabetes Association conference in New Orleans.

Lilly had previously disclosed results from the two studies presented Saturday showing patients with obesity lost 28% of body weight and adults with Type 2 diabetes had significant reductions in blood sugar levels.

In one of the studies, 2% of patients with diabetes who took the lowest dose of retatrutide had major adverse cardiovascular events. The detailed results, published Saturday in The Lancet, said those events were not necessarily caused by the drug.

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Parris Island

Port Royal sergeant injured in accidental gun discharge

He suffered injuries to his hand and thigh when the gun discharged.

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A Port Royal police sergeant was recovering after being injured in an accidental firearm discharge at the Port Royal Police Department on Thursday afternoon.

Staff Sgt. Steven Colson was injured about 2 p.m. June 4 while cleaning his department-issued pistol at police headquarters, according to a department release.

The bullet struck Colson in his left hand before entering his left leg near the knee. Officers inside the building heard the gunshot and responded, calling Beaufort County Emergency Medical Services and the Port Royal Fire Department.

Meyers described the incident as a “very, very unfortunate accident.” He said Colson was later transferred to the Medical University of South Carolina and was expected to be released over the weekend.

Colson is a staff sergeant with the department and a military veteran. He has worked for the Port Royal Police Department for about 10 to 11 years.
Asia

Xi arrives in North Korea for talks with Kim

The trip was Xi’s first visit to North Korea in seven years.

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Chinese President Xi Jinping arrived in Pyongyang on Monday for a two-day state visit and expected talks with North Korean leader Kim Jong Un, in a closely watched meeting as both countries face separate tensions with the United States.

China’s Xinhua News Agency said Kim and his wife, Ri Sol Ju, welcomed Xi and his wife, Peng Liyuan, at Pyongyang’s international airport.

He was expected to hold a summit with Kim in their first meeting since September, when they met in Beijing after attending a military parade with Russian President Vladimir Putin and other foreign leaders.

No agenda was announced.

China has long been North Korea’s main economic partner and diplomatic supporter. Analysts say Beijing has not fully enforced U.N. sanctions on North Korea. This year marks 65 years since the countries signed a mutual defense treaty.

In an article published Monday in Rodong Sinmun, North Korea’s main newspaper, Xi said the two countries should strengthen strategic cooperation, oppose “hegemonism and coercive politics,” and pursue a multipolar world.

The visit came after Xi’s meetings last month in Beijing with President Donald Trump and Putin. The White House said Trump and Xi reaffirmed a shared goal of denuclearizing North Korea, while China said only that they discussed the nuclear issue on the Korean Peninsula. On Sunday, Kim’s sister, Kim Yo Jong, called the U.S. account “false information.”

North Korea has expanded weapons development since Kim’s diplomacy with Trump collapsed in 2019. Last week, Kim unveiled a plant to produce nuclear materials and called for expanding the country’s nuclear forces. On Sunday, Kim Yo Jong called U.S. calls for denuclearization an “escapist and anachronistic dream.”
Europe

Ukraine says road netting topped 500 miles in 2025

The barriers can help stop drones, but they are not fully effective.

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Ukraine’s Defense Ministry said Saturday that it had installed 822 kilometers, or about 510 miles, of anti-drone protection on frontline roads this year.

The total exceeded the roughly 447-mile drive from Florida’s Georgia border to Key West. The ministry said 211 kilometers, or about 131 miles, were installed in May alone.

“Reliable logistics near the front remains a constant priority. We are systematically working to protect key routes,” the ministry said.

Ukraine’s State Special Transport Service built wooden or metal frames along roads and draped mesh over them to form tunnels that stretched for miles.

The netting, often repurposed from farming or fishing mesh and donated by Western allies, was used to entangle small attack drones. Ukrainian and Russian forces first used nets to protect armored vehicles, then in late 2023 expanded their use to fixed positions as fiber-optic drones became more common and electronic warfare became less effective.

Russia began building mesh tunnels at scale on roads under its control, with footage in spring 2025 showing covered highways in Donetsk. Ukraine also expanded the tactic. Its Defense Ministry said last month that it was laying 5.2 miles of netting per day, up from 2.4 miles per day in 2025.

Based on the ministry’s figures, Ukraine has laid at least 720 miles of anti-drone netting over the past two years.

Repeated attacks can tear openings in the mesh, allowing explosive-laden drones to get through and remain near passing vehicles or troops.
Middle East

Israel strikes Beirut suburbs after ceasefire talks

Iran had warned that a Beirut strike could renew wider regional fighting, as Pakistan sought to restart U.S.-Iran talks.

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Israel struck Beirut’s southern suburbs on Sunday, days after Lebanese and Israeli officials meeting in Washington renewed a ceasefire agreement, and despite a U.S. request not to attack Lebanon’s capital.

No casualties were immediately reported.

Prime Minister Benjamin Netanyahu’s office said the strikes were retaliation for fire toward northern Israel that it blamed on the Iran-backed Hezbollah militant group. It said the targets were “command centers” in the densely populated area.

An Israeli strike hit a residential building near a gas station, damaging four of its seven floors. The Lebanese military cordoned off the area after an unexploded munition was found in the rubble. Ambulances were at the scene, though no bodies or wounded people were immediately seen.

Israel had twice struck Beirut’s southern suburbs since an earlier Lebanon-Israel agreement took effect April 17.

Israel said Monday it would strike the southern suburbs after Hezbollah claimed attacks in northern Israel, but urgent talks through Washington halted the operation on the condition that Hezbollah stop targeting Israeli border towns.

In an interview taped Friday and aired Sunday on NBC’s “Meet the Press,” President Donald Trump said, “I’d like to see Lebanon have a better life. I’d like to see a more surgical attack on Hezbollah. I think it should be more surgical.” He added that he was “not demanding” that Lebanon be included in a short-term deal to extend the ceasefire in the Iran war.

More than 3,500 people have been killed in Lebanon since the war began March 2, according to the report. More than 1 million people have been displaced. The fighting has also killed at least 31 Israeli soldiers and three civilians.
Asia

Philippines quake kills 15, prompts tsunami alerts

Tsunami warnings were issued in the Philippines, Indonesia, and Japan.

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A magnitude 7.8 earthquake struck off the Philippine island of Mindanao shortly before 7:40 a.m. local time Monday, killing at least 15 people, damaging buildings, and prompting tsunami alerts across Asia.

The U.S. Geological Survey reported the quake occurred at 23:40 GMT Sunday. The Philippine Institute of Volcanology and Seismology said the initial quake was followed by more than an hour of aftershocks.

General Santos, a city of 722,000 in southern Mindanao, was among the hardest-hit areas. The Philippine seismology agency said the city, in the Soccsksargen region, experienced the quake at level 7, or “very strong,” on its 10-point intensity scale.

The Pacific Tsunami Warning Center said waves of up to 3 meters (9.8 feet) could hit parts of the Philippines, while waves of up to 1 meter (3.3 feet) were possible in parts of Indonesia and Malaysia. By 04:00 GMT, the center said the tsunami risk had passed, though coastal residents should remain alert and follow local authorities’ instructions.

The largest tsunami waves were recorded in Indonesia’s North Sulawesi province at about 0.83 meters Monday morning, the center said. Indonesia later canceled warnings for North Sulawesi, Gorontalo, and the Sangihe Islands. Officials in Guam and the Northern Mariana Islands also canceled earlier warnings, while a tsunami advisory remained in place for Japan’s southern coast and outlying islands.
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Prada unveils NASA moon mission undergarment

Prada’s move came as the luxury goods sector faced pressure.

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Prada on Sunday unveiled an inner-layer garment designed for NASA astronauts headed to the moon, part of the Italian fashion house’s effort to expand into the space industry.

The body-hugging suit, developed with Houston-based space infrastructure company Axiom Space, has ventilation tubes knitted into the garment.

“We have really a broad spectrum of capability and know-how,” Lorenzo Bertelli, Prada’s chief marketing officer, said at an event at Prada’s Manhattan store, seated beside a mannequin wearing the new Liquid Cooling and Ventilation Garment.

Expertise for developing space exploration products “can come from lots of seemingly unrelated industries,” said Jonathan Cirtain, chief executive of Axiom Space.

The garment followed Prada’s 2024 unveiling of a spacesuit expected to be used for NASA’s Artemis 4 moon landing mission in 2028.

Luxury brands have long drawn inspiration from space travel, but Prada has gone “beyond inspiration into an actual partnership” as the space exploration and tourism industries develop, said Thomai Serdari, a luxury brand strategist and marketing professor at New York University’s Stern School of Business.

Serdari said Prada’s interest in the space industry reflected two factors: reaching affluent consumers considering space travel, and associating the brand with avant-garde ideas. Companies including Jeff Bezos’ Blue Origin and Elon Musk’s SpaceX have pursued space tourism aimed at wealthy customers.

After two years of contraction, the luxury goods industry has shown signs of stabilizing until the Iran war began at the end of February, disrupting travel and reducing luxury spending beyond the Middle East.
Finance & Markets

Oil jumps, global stocks fall as Israel-Iran fighting

On Friday, the S&P 500 fell 2.6%, its biggest one-day decline since Oct. 10, when the Trump administration threatened 100% tariffs on imported goods from China.

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Global shares fell Monday after Wall Street posted its biggest one-day drop since October, while oil prices rose more than $4 as fighting between Israel and Iran intensified.

South Korea’s Kospi led the declines, falling 8.3% on heavy selling in technology shares. Samsung Electronics dropped 10.2%, and SK Hynix fell 7.7%.

Oil prices climbed after Israel launched airstrikes early Monday on central and western Iran following missile fire.

Brent crude, the international benchmark, rose $4.60 to $97.69 a barrel. U.S. benchmark crude gained $4.13 to $94.67 a barrel.

U.S. stock futures were mixed early Monday, with futures for the S&P 500 up 0.2% and futures for the Dow Jones Industrial Average down 0.3%.

A strong jobs report raised expectations that the Federal Reserve could increase interest rates this year, adding to concerns about whether the rally in artificial intelligence-related technology shares can continue.

The Dow fell 1.4% Friday, and the Nasdaq composite lost 4.2%.

In currency trading early Monday, the U.S. dollar edged down to 160.23 Japanese yen from 160.25 yen. The euro rose to $1.1521 from $1.1515.
US

Vance says Kirk killing shaped family decision

The Vances appeared to be the first people seen publicly with Erika Kirk after the shooting.

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Vice President JD Vance said in an excerpt from his new book, published by The Wall Street Journal, that the killing of political activist Charlie Kirk influenced his and second lady Usha Vance’s decision to have a fourth child.

In the excerpt, Vance referred to Kirk as his “best friend” in politics. He wrote, “one life was stolen from us, but another was given.”

Kirk, 31, was shot and killed during a Turning Point USA event in September at Utah Valley University.

Vance wrote that he relied on Kirk for counsel during the early days of the 2024 election campaign as his family adjusted to rising public attention. He said his 7-year-old son struggled with the change and recalled telling Kirk that “sometimes I feel like I ruined his life without even asking him.”

According to the excerpt, Vance first learned of the shooting through group chats that included Kirk. Vance wrote that when he left his office, his staff looked like they had “seen a ghost,” and his chief of staff told him, “Charlie was shot” and “It doesn’t look good.”

Vance also wrote that comments from Kirk’s widow, Erika Kirk, after her husband’s death led him to reflect on his own mortality and what his children would remember about him if he died in a similar way.
Health

Lilly says retatrutide eased sleep apnea, knee pain

Retatrutide is Lilly’s experimental triple-hormone drug. It targets glucagon-like peptide-1, or GLP-1, glucose-dependent insulinotropic polypeptide, or GIP, and glucagon receptors.

Full story +

Eli Lilly presented trial results on Saturday showing its experimental obesity drug retatrutide reduced sleep apnea severity, eased knee osteoarthritis pain, and supported weight loss.

In a Phase 3 trial, Lilly said a weekly injection of retatrutide reduced moderate-to-severe obstructive sleep apnea severity by 60.6% in adults with obesity. Lilly’s older drug Zepbound is already approved for that condition.

In the same trial, Lilly said retatrutide reduced knee osteoarthritis pain by up to 73.1%. The results were presented at the American Diabetes Association conference in New Orleans.

Lilly had previously disclosed results from the two studies presented Saturday showing patients with obesity lost 28% of body weight and adults with Type 2 diabetes had significant reductions in blood sugar levels.

In one of the studies, 2% of patients with diabetes who took the lowest dose of retatrutide had major adverse cardiovascular events. The detailed results, published Saturday in The Lancet, said those events were not necessarily caused by the drug.
US

6 injured in stabbings near Penn Station, suspect held

Amtrak Police, which is leading the investigation, said a suspect had been taken into custody.

Full story +

A suspect was in custody after multiple people were stabbed near New York City’s Penn Station on Sunday evening, leaving one person seriously injured, officials said.

The Fire Department of New York said emergency crews responded to West 33rd Street and Seventh Avenue at 7:02 p.m. after reports that a person had stabbed multiple people.

According to the department, six civilians were injured: one seriously, two with moderate injuries, and three with minor injuries.

Five patients were taken to Bellevue Hospital, including the person with serious injuries and two with moderate injuries. A sixth patient with minor injuries was taken to NewYork-Presbyterian/Weill Cornell Medical Center.